Sarcoplasm calcium binding protein (SARC)
entry list
alignment
Sarcoplasm calcium binding protein (SARC) binds three Ca2+ or Mg2+
ions competitively. It is found both as a monomer and as a dimer; it
may function as a calcium buffer. Neither the sequences of its four
EF-hands nor of the three interdomain linkers closely resemble other
EF- hands or linkers. Crystal structures are available of SARC from
the sandworm, Nereis diversicolor, [68] and from amphioxus,
Branchiostoma lanceolatum, [69]. Although the sequences share only 22%
overall identity, the main chain traces of the two are nearly
superimposable. All four domains have Ca2+ bound. The hydrophobic
faces of lobes 1,2 and 3,4 contact one another.