Regulatory Light Chain (RLC)

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Regulatory light chain (RLC) of vertebrate smooth and cardiac myosins do not bind calcium but are an alternate source of calcium regulation via a CAM activated kinase. Comparison of the crystal structure of molluscan RLC with a Ca2+ ion bound in EF-hand 1 with both chicken ELC and RLC complexed with the S1 fragment of myosin has permitted Houdusse et al.[10] to present a model of ELC and RLC complexed with myosin in the active and inactive states.