PKD2 gene product (PKD)
The PKD2 gene product (PKD) has 968 residues. Mutations in this
gene in humans segregate with polycystic kidney disease . The
homolog, PKD1, constitutes a voltage-activated calcium (and sodium)
channel in Caenorhabditis elegans. PKD has six membrane spanning
helices. Two EF-hands follow the sixth transmembrane helix, a hundred
residues from the C- terminus.