PKD2 gene product (PKD)

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The PKD2 gene product (PKD) has 968 residues. Mutations in this gene in humans segregate with polycystic kidney disease [84]. The homolog, PKD1, constitutes a voltage-activated calcium (and sodium) channel in Caenorhabditis elegans. PKD has six membrane spanning helices. Two EF-hands follow the sixth transmembrane helix, a hundred residues from the C- terminus.