Nucleobindin and DNA-binding protein, NEFA (NUBN)

entry list
Nucleobindin (NUBN) was initially identified in KML1-7 cells from MRL/1 mice, which are prone to develop lupus erythematosis and produce elevated levels of anti-dsDNA and anti- ssDNA antibodies [40]. NUBN has 455 residues. There is a signal sequence at the N- terminus followed by a two hundred residue domain of unknown homolgy, two canonical EF- hands, then seven heptad repeats as found in a coiled coil (leucine zipper). The first EF-hands of NUBN and of CRGP are most closely related to one another. The nuclear EF-hand acidic (NEFA) gene product is closely related to NUBN; its function is unknown [41].