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LAV1 (LAV) cDNA encodes a 355 residue protein. Different isoforms are expressed in amoebae and in plasmodia of Physarum polycephalum [78]. Domains 2 and 4 of LAV most closely resemble one another. Although LAV appears not to be congruent with any other EF- hand protein, its interdomains 1,2 and 3,4 resemble 1,2 and 3,4 of CTER. Linker 2,3 consists of a sole Leu. This places severe constraints on the spatial relationship between the lobe 1,2 and the C-terminal lobe. The function of LAV is not known and no homolog has been identified for the ~200 residues at its N-terminus.