Trichohyalin and profilaggrin (HYFL)

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Trichohyalin and profilaggrin (HYFL) have two EF-hands at their N-termini, both of which are congruent with S100 and with ICBP. However, trichohyalin contains seven tandemly repeated domains homologous to involucrin at its C-terminus [37]. Profilaggrin has ten to twelve filaggrin domains at its C-terminus [38]. Both associate with keratin intermediate filaments.