Ras guanyl nucleotide-releasing protein (GRP)
entry list
alignment
Ras guanyl nucleotide-releasing protein (GRP) has 795 residues and
contains a homolog of a REM domain, a CDC25 domain, two EF-hands, and
a diacylglycerol binding domain [83]. The two EF-hand loops are
canonical and are expected to bind calcium. Helices E1 and F2 appear
conventional. However, there are only 15 residues for helices F1 and
E2. One or both of these helices is truncated and the relationship
between the two EF-hands is unclear. Rat fibroblasts expressing the
RasGRP encoding gene vector are transformed. Addition of a DAG analog
causes sustained activation of Ras-Erk signaling and changes in cell
morphology.