Gene product of eps15 (EP15)

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The gene product of eps15 (EP15) encodes a protein of 897 residues. The first domain of 282 residues contains a candidate phosphorylation site as well as six putative EF-hands, two of which are inferred to bind calcium. EP15 is phosphorylated on tyrosine following EGFR activation by EGF in vivo, or directly by EGFR in vitro [53].