Essential Light Chain (ELC)
entry list
alignment
Essential light chain (ELC) has two alternate mRNA splice forms. A1
(long) has ~55 residues before the first EF-hand; A2 (short) has about
ten. The ancestor to vertebrates had four isoforms of ELC. The
skeletal form is most divergent, then the smooth muscle form. The
cardiac atrial and cardiac ventricular forms are most similar.
Molluscan ELC is inferred to bind calcium in its first EF-hand;
vertebrate ELC's do not bind calcium [9].