Calbindin D28k (CLBN)

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Calbindin D28k (CLBN) is found in intestinal epithelium and may be involved in transcellular transport of calcium; however, it is not congruent with ICBP, sometimes referred to as calbindin D9k. Domains 1, 3 & 5 and domains 2, 4 & 6 are more closely related. Interdomains 1,2 and 3,4 and 5,6 are similar and are inferred to be homologous. CLBN appears to have evolved by two duplications and fusions from a two domain precursor. The six domains, individually synthesized, aggregate in pairwise combination to approximate the spectral properties of the intact CLBN [52].