Calbindin D28k (CLBN)
Calbindin D28k (CLBN) is found in intestinal epithelium and may be
involved in transcellular transport of calcium; however, it is not
congruent with ICBP, sometimes referred to as calbindin D9k. Domains
1, 3 & 5 and domains 2, 4 & 6 are more closely related. Interdomains
1,2 and 3,4 and 5,6 are similar and are inferred to be homologous.
CLBN appears to have evolved by two duplications and fusions from a two
domain precursor. The six domains, individually synthesized, aggregate
in pairwise combination to approximate the spectral properties of the
intact CLBN .