Calsenilin (CALS)

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Calsenilin (CALS) binds both presenilin 1 (PS1) and presenilin 2 (PS2) in a calcium dependent manner. Most early onset familial Alzheimer cases are caused by mutations in PS1 or PS2. CALS may mediate the role of PS2 in apoptosis and _-amyloid formation [23]. CALS is 251 residues long and contains four EF-hands. No homolog of its first 80 residues has been identified. The sequences of CALS and of DREM are quite similar and all domains cluster together, figure 6. They are tentatively placed in different subfamilies because of the apparent differences in function.