Aequorin (AEQ)
entry list
alignment
Aequorin (AEQ) (EC 1.13.12.5 renilla-luciferin 2-monooxygenase) is a
calcium-dependent photoprotein that oxidizes luciferin
(coelenterazine) and thereby produces the luminescence of the marine
coelenterate, Aequoria victoria [70]. In the anthozoan, Renilla
reniformis, calcium induced bioluminescence involves two proteins _
luciferase and luciferin binding protein. LBP has four EF-hands but
lacks the luciferase activity of aequorin [71]. AEQ has only a few
residues N- and C-terminal to the four EF-hand domains; perhaps its
luciferase activity is associated with its aberrant second domain.