Aequorin (AEQ)

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Aequorin (AEQ) (EC renilla-luciferin 2-monooxygenase) is a calcium-dependent photoprotein that oxidizes luciferin (coelenterazine) and thereby produces the luminescence of the marine coelenterate, Aequoria victoria [70]. In the anthozoan, Renilla reniformis, calcium induced bioluminescence involves two proteins _ luciferase and luciferin binding protein. LBP has four EF-hands but lacks the luciferase activity of aequorin [71]. AEQ has only a few residues N- and C-terminal to the four EF-hand domains; perhaps its luciferase activity is associated with its aberrant second domain.