_-Actinin (ACTN)

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_-Actinin (ACTN) cross links actin filaments non-covalently. It is a homodimer whose subunits assemble in an antiparallel fashion to form a rod like structure [43]. The difference between nonmuscle and muscle forms is that the cross linking activity of the former is completely inhibited by _M calcium, while the activity of the muscle form is not calcium sensitive. Both forms have two EF-hand domains at their C-terminii.